Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Biological ActivityAnti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
Rivera et al.
Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
Zhao et al.
Cancer Res., 2010;70:3372
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours.
Issaeva et al.
Nature Med., 2004;10:1321
Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer.
Citation for RITA
The citations listed below are publications that use Tocris products. Selected citations for RITA include:
1 Citation: Showing 1 - 1
Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
Authors: Thotala Et al.
Cell Death Differ 2012;19:387
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