Anti-tumor agent that binds wild-type p53 (Kd
= 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro
and in vivo
. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo
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All Tocris products are intended for laboratory research use only.
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
Rivera et al.
Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
Zhao et al.
Cancer Res., 2010;70:3372
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours.
Issaeva et al.
Nature Med., 2004;10:1321
The citations listed below are publications that use Tocris products. Selected citations for RITA include:
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