Catalog Number: 2443
Alternate Names: NSC 652287
Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Biological Activity
Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.
Technical Data
  • M.Wt:
    292.37
  • Formula:
    C14H12O3S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    213261-59-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
    Rivera et al.
    Biochem.Pharmacol., 1999;57:1283
  2. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
    Zhao et al.
    Cancer Res., 2010;70:3372
  3. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours.
    Issaeva et al.
    Nature Med., 2004;10:1321
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RITA include:

1 Citations: Showing 1 - 1

  1. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
    Authors: Thotala Et al.
    Cell Death Differ 2012;19:387

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