Catalog Number: 1053
Alternate Names: Metanicotine, TC-2403
Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Biological Activity
A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.
Technical Data
  • M.Wt:
    252.27
  • Formula:
    C10H14N2.C2H2O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    220662-95-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
    Bencherif et al.
    J.Pharmacol.Exp.Ther., 1996;279:1413
  2. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.
    Damaj et al.
    J.Pharmacol.Exp.Ther., 1999;291:390
  3. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization.
    Lippiello et al.
    J.Pharmacol.Exp.Ther., 1996;279:1422
Citations:

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