Ro 3306

Catalog # Availability Size / Price Qty
Ro 3306 | CAS No. 872573-93-8 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk1 inhibitor

Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

Ro 3306 is an ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 μM for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). RO 3306 also improves homology-directed repair (HDR) -mediated gene editing in hematopoietic stem and progenitor cells.

Technical Data

Soluble to 20 mM in DMSO with gentle warming
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ro 3306

The citations listed below are publications that use Tocris products. Selected citations for Ro 3306 include:

10 Citations: Showing 1 - 10

  1. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
    Authors: Liccardi Et al.
    Mol Cell  2019;73:413
  2. Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1.
    Authors: Meyer Et al.
    FASEB J  2019;33:2796
  3. PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.
    Authors: Smith Et al.
    Cell Rep  2019;28:2206
  4. Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.
    Authors: Sacristan Et al.
    Nat Cell Biol  2018;20:800
  5. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.
    Authors: Karki
    Nat Commun  2017;8:15803
  6. Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation.
    Authors: Shukla Et al.
    Nat Commun  2015;6:8077
  7. JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.
    Authors: Ramkumar Et al.
    J Biol Chem  2015;290:29617
  8. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells.
    Authors: Silva Et al.
    Mol Cell  2015;14:1070
  9. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One  2014;9:e93046
  10. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
    Authors: Rossi Et al.
    Am J Physiol Gastrointest Liver Physiol  2013;49:1159


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