Catalog Number: 4181
Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Biological Activity
ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
    Kojima et al.
    Cancer Sci., 2009;100:1128
  2. CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage.
    Yu et al.
    Cancer Res., 2012;72:5448
  3. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.
    Vassilev et al.
    Proc.Natl.Acad.Sci., 2006;103:10660

The citations listed below are publications that use Tocris products. Selected citations for Ro 3306 include:

5 Citations: Showing 1 - 5
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  1. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.
    Authors: Karki
    Nat Commun 2017;8:15803
  2. Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation.
    Authors: Shukla Et al.
    Nat Commun 2015;6:8077
  3. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells.
    Authors: Silva Et al.
    Mol Cell 2015;14:1070
  4. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One 2014;9:e93046
  5. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
    Authors: Rossi Et al.
    Am J Physiol Gastrointest Liver Physiol 2013;49:1159

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