Ro 3306

  ( 6 citations )    
Product Datasheet
Catalog Number:4181
Chemical Name:5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Product Details
Citations (6)
Reviews
Biological Activity
ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).
Technical Data
  • M.Wt:
    351.45
  • Formula:
    C18H13N3OS2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    872573-93-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 3306 include:

6 Citations: Showing 1 - 6
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  1. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.
    Authors: Karki
    Nat Commun  2017;8:15803
  2. Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation.
    Authors: Shukla Et al.
    Nat Commun  2015;6:8077
  3. JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.
    Authors: Ramkumar Et al.
    J Biol Chem  2015;290:29617
  4. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells.
    Authors: Silva Et al.
    Mol Cell  2015;14:1070
  5. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One  2014;9:e93046
  6. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
    Authors: Rossi Et al.
    Am J Physiol Gastrointest Liver Physiol  2013;49:1159

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