RO-3

Catalog # Availability Size / Price Qty
3052/10
RO-3 | CAS No. 1026582-88-6 | P2X Receptor Antagonists
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Description: Selective P2X3 and P2X2/3 antagonist

Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine

Purity: ≥98%

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Biological Activity

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Technical Data

M.Wt:
302.37
Formula:
C16H22N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1026582-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Purinoceptors as therapeutic targets for lower urinary tract dysfunction.
    Ford et al.
    Br.J.Pharmacol., 2006;147:S132
  2. Painful purinergic receptors.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 2008;324:409
  3. Pharmacology of P2X channels.
    Gever et al.
    Eur.J.Physiol., 2006;452:513

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