Catalog Number: 3052
Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
Biological Activity
Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.
Technical Data
  • M.Wt:
    302.37
  • Formula:
    C16H22N4O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1026582-88-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purinoceptors as therapeutic targets for lower urinary tract dysfunction.
    Ford et al.
    Br.J.Pharmacol., 2006;147:S132
  2. Painful purinergic receptors.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 2008;324:409
  3. Pharmacology of P2X channels.
    Gever et al.
    Eur.J.Physiol., 2006;452:513

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