Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
Biological ActivityPositive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat et al.
Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site.
Knoflach et al.
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