Ro 67-4853

Catalog # Availability Size / Price Qty
4347/10
4347/50
Group I mGluR Modulators Small Molecule
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Description: Positive allosteric modulator of group I mGlu receptors

Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester

Purity: ≥99%

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Biological Activity

Positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).

Technical Data

M.Wt:
325.36
Formula:
C19H19NO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
302841-89-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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