Rotavirus Antibody - BSA Free

Novus Biologicals | Catalog # NB100-64396

Novus Biologicals
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Key Product Details

Species Reactivity

Virus

Applications

ELISA

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Format

BSA Free
View all Rotavirus Primary Antibodies »

Product Specifications

Immunogen

Five serotypes of group A Rotavirus strains Wa (serotype I), DS-1 (serotype II), Ito (III), HOCHI (IV) and 69M (VIII)

Specificity

NB100-64396 recognizes human rotavirus serotypes I, II, III, IV and VIII. Rotaviruses are RNA viruses from the family Reoviridae that are the the most common cause of gastroenteritis in infants. The nucleic acid is contained in a triple layered protein capsid consisting of outer capsid proteins, VP4 and VP7. Immunization was performed with live Rotavirus serotypes to avoid the risk of surface protein damage (VP7 and VP4).

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Rotavirus Antibody - BSA Free

Application
Recommended Usage

ELISA

1:500-1:5000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Rotavirus

Rotaviruses, members of the family Reoviridae, are a major cause of diarrhoea in young mammals. Rotavirus infections also result in economic losses in agriculture due to diarrhoea in calf, pig, sheep, and poultry rearing. Diarrhoea (or scours) due to the rotavirus Nebraska Calf Diarrhea Virus can affect calves up to 30 days of age or older. Diarrhoea begins 2 to 3 days after exposure. Diagnosis is by history, lesions (ulcers on the tongue, lips, and mouth) and diagnostic laboratory tests. Mortality rates may be as high as 50 percent, depending on the secondary bacteria present. Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Rotaviruses are 70 nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection; therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence.

Alternate Names

Major inner capsid protein VP6, VP6

Additional Rotavirus Products

Product Documents for Rotavirus Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Rotavirus Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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