Catalog Number: 3028
Chemical Name: 2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
Biological Activity
Competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

This product is sold in units of 560μg, equivalent to 1μmol.

Technical Data
  • M.Wt:
    562.27
  • Formula:
    C18H14BrN5NaO6PS
  • Solubility:
    Soluble to 20 mM in water and to 40 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    185246-32-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This product is sold in units of 560μg, equivalent to 1μmol.
Background References
  1. Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site.
    Wei et al.
    Biochemistry, 1996;35:16815
  2. Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins.
    Qi et al.
    Br.J.Pharmacol., 2007;152:1060
  3. The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells.
    Valtcheva et al.
    J.Biol.Chem., 2008;284:556
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rp-8-Br-PET-cGMPS include:

2 Citations: Showing 1 - 2
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  1. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One 2013;8:e82180
  2. Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores.
    Authors: Lin Et al.
    Cell 2008;37:770

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