RS 102895 hydrochloride

Catalog # Availability Size / Price Qty
2089/10
2089/50
RS 102895 hydrochloride | CAS No. 1173022-16-6 | Chemokine Receptor Antagonists
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Description: CCR2b chemokine receptor antagonist

Chemical Name: 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride

Purity: ≥99%

Product Details
Citations (5)
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Biological Activity

CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A, α1D and 5-HT1A receptors.

Technical Data

M.Wt:
426.86
Formula:
C21H21F3N2O2.HCl
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1173022-16-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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