RS 102895 hydrochloride

Key Product Details

Product Description

RS 102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC₅₀ values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC₅₀ values of 32 nM and 1.7 μM respectively. Also inhibits α_1A, α_1D and 5-HT_1A receptors.

Product Specifications for RS 102895 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 102895 hydrochloride

The following data is based on the product molecular weight 426.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.12 mL	15.62 mL	31.24 mL
3.75 mM	0.62 mL	3.12 mL	6.25 mL
7.5 mM	0.31 mL	1.56 mL	3.12 mL
37.5 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Mirzadegan Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 2000 PMID: 10770925
• Clark Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 1983 PMID: 6842505

Product Documents for RS 102895 hydrochloride