CCR2-selective chemokine receptor antagonist (IC50
values are 0.36 and 17.8 μ
M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50
values of 32 nM and 1.7 μ
M respectively. Also inhibits α1A
Soluble to 75 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones.
Clark et al.
Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists.
Mirzadegan et al.
The citations listed below are publications that use Tocris products. Selected citations for RS 102895 hydrochloride include:
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