(RS)-AMPA

  ( 16 citations )    
Product Datasheet
Catalog Number:0169
Chemical Name:(RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Product Details
Citations (16)
Supplemental Products
Reviews
Biological Activity
Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors.

Active Enantiomer, Inactive Enantiomer and Hydrobromide Salt also available.

Technical Data
  • M.Wt:
    186.17
  • Formula:
    C7H10N2O4
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    74341-63-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-AMPA include:

16 Citations: Showing 1 - 10
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  1. GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
    Authors: Guntupalli Et al.
    J Biol Chem  2017;292:8186
  2. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci  2015;9:409
  3. Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
    Authors: Netzahualcoyotzi and Tapia
    Acta Neuropathol Commun  2015;3:27
  4. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    Oncoscience  2015;1:82
  5. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One  2015;10:e0131430
  6. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    Stem Cell Reports  2014;3:282
  7. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  8. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Mol Cell Neurosci  2012;51:22
  9. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience  2011;189:305
  10. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
    Authors: Gangadharan Et al.
    J Clin Invest  2011;121:1608
  11. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  12. Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    Proc Natl Acad Sci U S A  2008;105:1038
  13. Regulated delivery of AMPA receptor subunits to the presynaptic membrane.
    Authors: Schenk Et al.
    EMBO J  2003;22:558
  14. Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
    Authors: Chen Et al.
    J Virol  2002;76:9407
  15. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
    Authors: Fedele Et al.
    Br J Pharmacol  1996;119:590
  16. Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum.
    Authors: Fedele and Raiteri
    Br J Pharmacol  1996;117:1133
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Tocris Small Molecules
Description Application Cat# Citations Images  

(S)-AMPA

0254 10  
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(R)-AMPA

0253  
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human GluR1 (NP_001107655) VersaClone cDNA

RDC1110
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Human GluR4 (NP_000820) VersaClone cDNA

RDC1213
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Human GluR3 (NP_000819) VersaClone cDNA

RDC1135
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