Catalog Number: 0169
Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Biological Activity
Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors.

Active Enantiomer, Inactive Enantiomer and Hydrobromide Salt also available.

Technical Data
  • M.Wt:
    186.17
  • Formula:
    C7H10N2O4
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    74341-63-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes.
    Honore et al.
    J.Neurochem., 1982;38:173
  2. New class of glutamate agonist structurally related to ibotenic acid.
    Krogsgaard-Larsen et al.
    Nature, 1980;284:64
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (RS)-AMPA include:

10 Citations: Showing 1 - 10
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  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci 2015;9:409
  2. Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
    Authors: Netzahualcoyotzi and Tapia
    Acta Neuropathol Commun 2015;3:27
  3. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    Oncoscience 2015;1:82
  4. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One 2015;10:e0131430
  5. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    Stem Cell Reports 2014;3:282
  6. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Mol Cell Neurosci 2012;51:22
  7. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience 2011;189:305
  8. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem 2010;285:35606
  9. Endocytosis and recycling of AMPA receptors lacking GluR2/3.
    Authors: Biou Et al.
    Proc Natl Acad Sci U S A 2008;105:1038
  10. Regulated delivery of AMPA receptor subunits to the presynaptic membrane.
    Authors: Schenk Et al.
    EMBO J 2003;22:558
Tocris Small Molecules
Description Application Cat# Citations Images  

(S)-AMPA

0254 6  
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(R)-AMPA

0253  
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