(RS)-AMPA

Catalog # Availability Size / Price Qty
0169/10
0169/50
Cat.No. 0169 - (RS)-AMPA | C7H10N2O4 | CAS No. 74341-63-2
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Description: Selective AMPA agonist

Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Purity: ≥99%

Product Details
Citations (16)
Supplemental Products
Reviews

Biological Activity

Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors.

Active Enantiomer, Inactive Enantiomer and Hydrobromide Salt also available.

Technical Data

M.Wt:
186.17
Formula:
C7H10N2O4
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
74341-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

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Citations for (RS)-AMPA

The citations listed below are publications that use Tocris products. Selected citations for (RS)-AMPA include:

16 Citations: Showing 1 - 10

  1. GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
    Authors: Guntupalli Et al.
    J Biol Chem  2017;292:8186
  2. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci  2015;9:409
  3. Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
    Authors: Netzahualcoyotzi and Tapia
    Acta Neuropathol Commun  2015;3:27
  4. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    Oncoscience  2015;1:82
  5. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One  2015;10:e0131430
  6. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    Stem Cell Reports  2014;3:282
  7. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  8. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
    Authors: Fakira Et al.
    Mol Cell Neurosci  2012;51:22
  9. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
    Neuroscience  2011;189:305
  10. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
    Authors: Gangadharan Et al.
    J Clin Invest  2011;121:1608

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