Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Biological ActivityPrototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors.
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The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes.
Honore et al.
New class of glutamate agonist structurally related to ibotenic acid.
Krogsgaard-Larsen et al.
Citations for (RS)-AMPA
The citations listed below are publications that use Tocris products. Selected citations for (RS)-AMPA include:
16 Citations: Showing 1 - 10
GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
Authors: Guntupalli Et al.
J Biol Chem 2017;292:8186
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
Authors: Angelantonio Et al.
Front Cell Neurosci 2015;9:409
Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
Authors: Netzahualcoyotzi and Tapia
Acta Neuropathol Commun 2015;3:27
Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
Authors: Nygaard Et al.
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
PLoS One 2015;10:e0131430
Generation of induced neuronal cells by the single reprogramming factor ASCL1.
Authors: Chanda Et al.
Stem Cell Reports 2014;3:282
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Authors: Fakira Et al.
Mol Cell Neurosci 2012;51:22
Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
Authors: Mahajan Et al.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Authors: Gangadharan Et al.
J Clin Invest 2011;121:1608
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
Authors: Maier Et al.
J Biol Chem 2010;285:35606
Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Authors: Biou Et al.
Proc Natl Acad Sci U S A 2008;105:1038
Regulated delivery of AMPA receptor subunits to the presynaptic membrane.
Authors: Schenk Et al.
EMBO J 2003;22:558
Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
Authors: Chen Et al.
J Virol 2002;76:9407
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Authors: Fedele Et al.
Br J Pharmacol 1996;119:590
Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum.
Authors: Fedele and Raiteri
Br J Pharmacol 1996;117:1133
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