RSVA 405
Chemical Name: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid
Purity: ≥98%
Biological Activity
RSVA 405 is an AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages.
Capiralla et al.
FASEB J., 2012;279:3791 -
Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-� peptide degradation.
Vingtdeux et al.
FASEB J., 2011;25:219 -
Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis.
Vingtdeux et al.
Mol Med, 2011;17:1022
Product Datasheets
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Citation for RSVA 405
The citations listed below are publications that use Tocris products. Selected citations for RSVA 405 include:
1 Citation: Showing 1 - 1
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Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
Authors: Dai Et al.
Autophagy 2017;13:1435
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