RSVA 405

Key Product Details

Product Description

RSVA 405 is an AMP-activated protein kinase (AMPK) activator (EC₅₀ = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC₅₀ = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

Product Specifications for RSVA 405

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RSVA 405

The following data is based on the product molecular weight 312.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.40 mL	32.01 mL	64.03 mL
2.5 mM	1.28 mL	6.40 mL	12.81 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
25 mM	0.13 mL	0.64 mL	1.28 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vingtdeux Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med 2011 PMID: 21647536
• Capiralla Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FASEB J. 2012 PMID: 22909341
• Vingtdeux Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J. 2011 PMID: 20852062

Product Documents for RSVA 405