RSVA 405

  ( 1 citations )    
Product Datasheet
Catalog Number:5138
Chemical Name:2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid
Product Details
Citations (1)
Reviews
Biological Activity
AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.
Technical Data
  • M.Wt:
    312.37
  • Formula:
    C17H20N4O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    140405-36-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RSVA 405 include:

1 Citations: Showing 1 - 1

  1. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
    Authors: Dai Et al.
    Autophagy  2017;13:1435

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