RUNX1T1/ETO Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-30717

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all RUNX1T1/ETO Primary Antibodies »

Product Specifications

Immunogen

between 554 and 604

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RUNX1T1/ETO Antibody - BSA Free

RUNX1T1/ETO Antibody

Western Blot:[NBP3-30717]-

Western Blot:[NBP3-30717]-Detection of human ETO by western blot and immunoprecipitation. Samples: Whole cell lysate from HEK293T, Jurkat and HeLa cells. Antibodies: Affinity purified rabbit anti-ETO antibody used for WB at 0. 4 µg/ml and 1 µg/ml and used for IP at 6 µg/mg lysate. ETO was also immunoprecipitated by rabbit anti-ETO antibody, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds.

Applications for RUNX1T1/ETO Antibody - BSA Free

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-citrate/phosphate buffer, pH 7 to 8

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: RUNX1T1/ETO

RUNX1T1 / ETO is encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Alternate Names

AML1T1protein CBFA2T1, CBFA2T1Cyclin-D-related protein, CDRMGC2796, core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclinD-related, DKFZp564B213, Eight twenty one protein, ETOFLJ33145, MTG8acute myelogenous leukemia 1 translocation 1, cyclin-D related, Protein ETO, Protein MTG8, runt-related transcription factor 1; translocated to, 1 (cyclin D-related), Zinc finger MYND domain-containing protein 2, ZMYND2myeloid translocation gene on 8q22

Gene Symbol

RUNX1T1

Additional RUNX1T1/ETO Products

Product Documents for RUNX1T1/ETO Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for RUNX1T1/ETO Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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