RXR beta/NR2B2 Antibody

Novus Biologicals | Catalog # NB100-1467

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all RXR beta/NR2B2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence CRDGMGDSGRDSRSP corresponding to internal region according to NP_068811.1.

Specificity

This antibody is expected to recognise an epitope corresponding to aa 70-83 of human RXR beta protein and does not cross-react with either RXR alpha or gamma.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for RXR beta/NR2B2 Antibody

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467] - Staining (1ug/ml) of A431 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467] - (1ug/ml) of A431 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467]

Western Blot: RXR beta/NR2B2 Antibody [NB100-1467] - HEK293 overexpressing RXRB and probed with (mock transfection in first lane).

Applications for RXR beta/NR2B2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:128000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 55 kDa band observed in A431 lysates (calculated MW of 56.9 kDa band according to NP_068811.1). In transfected HEK293 transiently expressing RXRB a band of approx. 60 kDa is observed. This band is not observed in the non-transfected HEK293.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RXR beta/NR2B2

Retinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. The RXR subfamily consists of at least three similar genes, RXR alpha, RXR beta and RXR gamma, all of which control transcription of target genes mediated by retinoids. RXR beta controls expression of many genes that respond to hormones and vitamins, including thyroid hormone, estrogen, retinoids and vitamin D. RXR beta controls a wide array of genes because of its ability to heterodimerize with other hormone receptors including the thyroid hormone receptor (THR), vitamin D receptor (VDR) and retinoic acid receptor (RAR).

Long Name

Retinoid X Receptor, beta

Alternate Names

H-2RIIBP, NR2B2, RXRB

Entrez Gene IDs

6257 (Human)

Gene Symbol

RXRB

UniProt

NP_068811. (Human)

Additional RXR beta/NR2B2 Products

Product Documents for RXR beta/NR2B2 Antibody

Certificate of Analysis

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Product Specific Notices for RXR beta/NR2B2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for RXR beta/NR2B2 Antibody

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