RXR gamma/NR2B3 Antibody

Novus Biologicals | Catalog # NB100-1468

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all RXR gamma/NR2B3 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence RQRSRERAESEAEC corresponding to internal region according to NP_008848.1.

Specificity

This antibody is expected to recognise an epitope corresponding to aa 213-226 of human RXR gamma protein (hinge region) and does not cross-react with either RXR alpha or beta.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for RXR gamma/NR2B3 Antibody

Western Blot: RXR gamma/NR2B3 Antibody [NB100-1468]

Western Blot: RXR gamma/NR2B3 Antibody [NB100-1468]

Western Blot: RXR gamma/NR2B3 Antibody [NB100-1468] - (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for RXR gamma/NR2B3 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

1-3 ug/ml
Application Notes
WB: Approx. 65 kDa band observed in HeLa lysates (calculated MW of 50.9 kDa band according to NP_008848.1).Primary incubation was 1 hour. Some bands of unknown identity were also consistently observed around 37 kDa. These bands were successfully blocked by incubation with the immunising peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RXR gamma/NR2B3

Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.

Long Name

Retinoid X Receptor, gamma

Alternate Names

NR2B3, RXRG

Entrez Gene IDs

6258 (Human)

Gene Symbol

RXRG

UniProt

NP_008848. (Human)

Additional RXR gamma/NR2B3 Products

Product Documents for RXR gamma/NR2B3 Antibody

Certificate of Analysis

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Product Specific Notices for RXR gamma/NR2B3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for RXR gamma/NR2B3 Antibody

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