S 18886

Catalog # Availability Size / Price Qty
5568/10
Cat.No. 5568 - S 18886 | C20H22ClNO4S | CAS No. 165538-40-9
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Description: Potent thromboxane A2 (TP) antagonist
Alternative Names: terutroban

Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid

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Biological Activity

Potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Technical Data

Formula:
C20H22ClNO4S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
165538-40-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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