S 18886

Key Product Details

Product Description

S 18886 is a potent thromboxane A₂ (TP) inhibitor (IC₅₀ = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Product Specifications for S 18886

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for S 18886

The following data is based on the product molecular weight 407.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.26 mL	24.52 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Wang Potent, long-acting cyclopentane-1,3-Dione thromboxane (A₂)-receptor antagonists. ACS Med.Chem.Lett. 2014 PMID: 25221659
• Cimetière Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9871769

Product Documents for S 18886