U 46619

Tocris Bioscience | Catalog # 1932

Potent, stable thromboxane A2 (TP) receptor agonist
Tocris Bioscience

Key Product Details

Description

Potent, stable thromboxane A2 (TP) receptor agonist

Alternative Names

9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
View all Prostanoid Receptor Agonists »

Product Description

U 46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Product Specifications for U 46619

Molecular Weight

350.50

Formula

C21H34O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

CAS Number

56985-40-1

PubChem ID

5311493

InChI Key

LQANGKSBLPMBTJ-BRSNVKEHSA-N

SMILES

O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 186 publications citing the usage of this product.

Product Documents for U 46619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for U 46619

For research use only

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