Catalog Number: 1932
Alternate Names: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Biological Activity
PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.
    Coleman et al.
    Br.J.Pharmacol., 1981;73:773
  2. Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.
    Morinelli et al.
    Am.J.Physiol., 1987;253:H1035
  3. Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor.
    Miggin and Kinsella
    Mol.Pharmacol., 2002;61:817
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