U 46619

  ( 6 citations )    
Product Datasheet
Catalog Number:1932
Alternate Names:9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
Chemical Name:(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
Technical Data
  • M.Wt:
    350.5
  • Formula:
    C21H34O4
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    56985-40-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for U 46619 include:

6 Citations: Showing 1 - 6
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  1. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats.
    Authors: Choi Et al.
    Scientific Reports  2016;6:31925
  2. A human platelet calcium calculator trained by pairwise agonist scanning.
    Authors: Lee and Diamond
    PLoS One  2015;11:e1004118
  3. Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence.
    Authors: Pike Et al.
    Sci Rep  2014;4:4705
  4. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Diabetes  2013;8:e66404
  5. S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
    Authors: Lacar Et al.
    PLoS One  2012;7:e31960
  6. Platelets present antigen in the context of MHC class I.
    Authors: Chapman Et al.
    J Immunol  2012;189:916

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