) analog that is a potent and stable thromboxane A2
(TP) receptor agonist (EC50
= 0.035 μ
M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro
preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα
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Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.
Coleman et al.
Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.
Morinelli et al.
Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor.
Miggin and Kinsella
The citations listed below are publications that use Tocris products. Selected citations for U 46619 include:
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