Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Biological ActivityU 46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.
Coleman et al.
Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.
Morinelli et al.
Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor.
Miggin and Kinsella
Citations for U 46619
The citations listed below are publications that use Tocris products. Selected citations for U 46619 include:
9 Citations: Showing 1 - 9
Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats.
Authors: Choi Et al.
Scientific Reports 2016;6:31925
A human platelet calcium calculator trained by pairwise agonist scanning.
Authors: Lee and Diamond
PLoS One 2015;11:e1004118
New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
Authors: Coleman Et al.
Mol Pharmacol 2014;86:342
Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence.
Authors: Pike Et al.
Sci Rep 2014;4:4705
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats.
Authors: White Et al.
Br J Pharmacol 2013;168:785
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.
Authors: Davis Et al.
Br J Pharmacol 2013;168:773
S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
Authors: Lacar Et al.
PLoS One 2012;7:e31960
Platelets present antigen in the context of MHC class I.
Authors: Chapman Et al.
J Immunol 2012;189:916
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