U 46619 (CAS 56985-40-1): R&D Systems
Catalog Number: 1932
Alternate Names: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Biological Activity
PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
Technical Data
  • M.Wt:
    350.5
  • Formula:
    C21H34O4
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    56985-40-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.
    Coleman et al.
    Br.J.Pharmacol., 1981;73:773
  2. Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.
    Morinelli et al.
    Am.J.Physiol., 1987;253:H1035
  3. Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor.
    Miggin and Kinsella
    Mol.Pharmacol., 2002;61:817
Citations:

The citations listed below are publications that use Tocris products. Selected citations for U 46619 include:

6 Citations: Showing 1 - 6
Filter your results:

  1. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats.
    Authors: Choi Et al.
    Scientific Reports 2016;6:31925
  2. A human platelet calcium calculator trained by pairwise agonist scanning.
    Authors: Lee and Diamond
    PLoS One 2015;11:e1004118
  3. Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence.
    Authors: Pike Et al.
    Sci Rep 2014;4:4705
  4. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Diabetes 2013;8:e66404
  5. S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
    Authors: Lacar Et al.
    PLoS One 2012;7:e31960
  6. Platelets present antigen in the context of MHC class I.
    Authors: Chapman Et al.
    J Immunol 2012;189:916

Have you used U 46619?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information