Catalog Number: 3518
Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
Biological Activity
Partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus.
    Lagostena et al.
    Neuropharmacology, 2008;54:676
  2. Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice.
    Marighetto et al.
    Psychopharmacology., 2008;197:499
  3. Improvement of contextual memory by S 24795 in aged mice: comparison with memantine.
    Beracochea et al.
    Psychopharmacology, 2008;196:555

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