(S)-(-)-Bay K 8644

Name: ( S )-(-)-Bay K 8644
Brand: Tocris Bioscience
SKU: 1546
Price: 415 USD
Availability: InStock

Tocris Bioscience | Catalog # 1546

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Citations (22)

Product Documents

CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644

View all Cav1.x Channel Activators »

Product Description

(S)-(-)-Bay K 8644 is a L-type Ca²⁺-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

Product Specifications for (S)-(-)-Bay K 8644

Molecular Weight

356.30

Formula

C₁₆H₁₅F₃N₂O₄

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

CAS Number

98625-26-4

PubChem ID

6603728

InChI Key

ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

SMILES

O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@H]1[C@]2=CC=CC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.63	100
	Ethanol	35.63	100

Preparing Stock Solutions for (S)-(-)-Bay K 8644

The following data is based on the product molecular weight 356.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

O'Neill and Bolger Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 1988 PMID: 2465070
Ravens and Schopper Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 1692975
Franckowiak The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 1985 PMID: 2412855

Product Documents for (S)-(-)-Bay K 8644

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for (S)-(-)-Bay K 8644

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for (S)-(-)-Bay K 8644

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