(S)-(-)-Bay K 8644
Chemical Name: (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Biological Activity(S)-(-)-Bay K 8644 is a L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.
Racemate and (R)-(+)-Enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.
Franckowiak et al.
Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644.
O'Neill and Bolger
Brain Res.Bull., 1988;21:865
Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.
Ravens and Schopper
Naunyn Schmiedebergs Arch.Pharmacol., 1990;341:232
Citations for (S)-(-)-Bay K 8644
The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Bay K 8644 include:
5 Citations: Showing 1 - 5
Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits.
Authors: Alles Et al.
Mol Pain 2018;14:1744806918765800
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Authors: Wei Et al.
Sci Rep 2017;7:981
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.
Authors: Burtscher Et al.
Biochim Biophys Acta 2014;1838:2053
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Authors: Landstrom Et al.
Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.
Authors: Chen Et al.
Nat Neurosci 2011;14:570
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