Chemical Name: (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Biological Activity(S)-(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (S)-(-)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
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Specificity of blebbistatin, an inhibitor of myosin II.
Limouze et al.
J.Muscle Res.Cell Motil., 2004;25:337
Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor.
Straight et al.
Dissecting cytokinesis with small molecules.
Straight et al.
Amer.Soc.Cell Biol.Abstr., 2002;:2515
Citations for (S)-(-)-Blebbistatin
The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Blebbistatin include:
3 Citations: Showing 1 - 3
P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
Authors: Schiff Et al.
Commun Biol 2019;2:162
Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho.
Authors: Bzymek Et al.
Sci Rep 2016;6:25016
Asymmetric division of contractile domains couples cell positioning and fate specification.
Authors: Ma?tre Et al.
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