(S)-(+)-Dimethindene maleate

Tocris Bioscience | Catalog # 1425

Selective M2 antagonist
Tocris Bioscience

Key Product Details

Description

Selective M2 antagonist
View all mAChR M2 Antagonists »

Product Description

(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells (see our protocol below) in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Product Specifications for (S)-(+)-Dimethindene maleate

Molecular Weight

408.50

Formula

C20H24N2.C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate

CAS Number

136152-65-3

PubChem ID

56972160

InChI Key

SWECWXGUJQLXJF-HFNHQGOYSA-N

SMILES

C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.24 100 with gentle warming

Preparing Stock Solutions for (S)-(+)-Dimethindene maleate

The following data is based on the product molecular weight 408.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.90 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 60 publications citing the usage of this product.

Product Documents for (S)-(+)-Dimethindene maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-(+)-Dimethindene maleate

For research use only

Citations for (S)-(+)-Dimethindene maleate

Customer Reviews for (S)-(+)-Dimethindene maleate (2)

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  • ESC culture
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ESC
    Verified Customer | Posted 11/23/2021
    In vitro cell culture addition. The image shows the morphology of ESC colonies after conversion by using the treatment condition. This condition supported the conversion and long-term maintenance of dome-shaped ESCs from primed ESCs.
    (S)-(+)-Dimethindene maleate 1425
  • Generation of EPS-blastoids
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: EPS
    Verified Customer | Posted 02/27/2020
    2uM
    (S)-(+)-Dimethindene maleate 1425

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