Minocycline hydrochloride
Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Purity: ≥98%
Biological Activity
Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.
Yang et al.
Cell., 2017;169:243 -
Targeting leukocyte MMPs and transmigration: MinCyc as a potential therapy for multiple sclerosis.
Brundula et al.
Brain, 2002;125:1297 -
MinCyc prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
Padi and Kulkarni
Eur.J.Pharmacol., 2008;601:79 -
MinCyc, a tetracy. derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
Tikka et al.
J.Neurosci., 2001;21:2580
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Citations for Minocycline hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:
2 Citations: Showing 1 - 2
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Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
Authors: Yaeger and Trussell
J Neurosci 2015;35:4741
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MinCyc does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.
Authors: Song Et al.
Hum Mol Genet 2015;11:25
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I have used the antibiotic minocycline to impair activation of microglia in the brain of mice. This drug has anti-inflammatory properties that block microglial reactivity, which can be easily confirmed by expression of the CD68 protein. The drug was diluted in PBS and injected i.p. (75 mg/kg) in mice, twice a day, for 7 days. The image shows that microglial cells (stained for Iba1) do not express CD68 (in red) after treatment with minocycline.
