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Minocycline hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:3268
Chemical Name:[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Product Details
Citations (2)
Reviews
Biological Activity
Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.
Technical Data
  • M.Wt:
    493.94
  • Formula:
    C23H27N3O7.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    13614-98-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
    Authors: Yaeger and Trussell
    J Neurosci  2015;35:4741
  2. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.
    Authors: Song Et al.
    Hum Mol Genet  2015;11:25

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