Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant.
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Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
Tikka et al.
Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis.
Brundula et al.
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
Padi and Kulkarni
The citations listed below are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:
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