Catalog Number: 3268
Chemical Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Biological Activity
Tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.
Technical Data
  • M.Wt:
    493.94
  • Formula:
    C23H27N3O7.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    13614-98-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
    Tikka et al.
    J.Neurosci., 2001;21:2580
  2. Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis.
    Brundula et al.
    Brain, 2002;125:1297
  3. Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
    Padi and Kulkarni
    Eur.J.Pharmacol., 2008;601:79
  4. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.
    Yang et al.
    Cell., 2017;169:243
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Minocycline hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
    Authors: Yaeger and Trussell
    J Neurosci 2015;35:4741
  2. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.
    Authors: Song Et al.
    Hum Mol Genet 2015;11:25

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