Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
Biological ActivitySAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
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Citations for SAG dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SAG dihydrochloride include:
3 Citations: Showing 1 - 3
Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
Authors: Madeline A Et al.
Nat Genet 2021;53:304-312
HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened.
Authors: Lucia Et al.
J Lipid Res 2020;61:492-504
Trisomy 21 Represses Cilia Formation and Function.
Authors: Joaquin M Et al.
Dev Cell 2018;46:641-650.e6
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