Potent Smoothened (Smo) receptor agonist (Kd
= 59 nM); antagonizes Cyclopamine
action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50
~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small molecule modulation of Smoothened activity.
Chen et al.
Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
Mak et al.
Stem Cells Int., 2012;2012:140427
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton et al.
The citations listed below are publications that use Tocris products. Selected citations for SAG include:
Showing Results 1 - 2 of 2