SAG

Catalog # Availability Size / Price Qty
4366/1
Smoothened Receptor Agonists Small Molecule
1 Image
Description: Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.

Technical Data

M.Wt:
490.06
Formula:
C28H28ClN3OS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
912545-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SAG

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3 Citations: Showing 1 - 3

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