Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Biological ActivityPotent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton et al.
Small molecule modulation of Smoothened activity.
Chen et al.
Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
Mak et al.
Stem Cells Int., 2012;2012:140427
Citations for SAG
The citations listed below are publications that use Tocris products. Selected citations for SAG include:
3 Citations: Showing 1 - 3
Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
Authors: Atzmon Et al.
Front Mol Neurosci 2018;11:336
Transcriptional comparison of human induced and primary midbrain DArgic neurons.
Authors: Xia Et al.
Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation.
Authors: Cortes Et al.
Nat Chem Biol 2015;5:471
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for SAG
There are currently no reviews for this product. Be the first to review SAG and earn rewards!
Have you used SAG?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image