Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro
. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50
= 10 μ
M). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1
phase; inhibits cell growth in human prostate carcinoma cells.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1.
Vogt et al.
Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.
Aburai et al.
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
Adhami et al.
Mol.Cell Ther., 2004;3:934
The citations listed below are publications that use Tocris products. Selected citations for Sanguinarine chloride include:
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