Catalog Number: 2302
Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Biological Activity
Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.
Technical Data
  • M.Wt:
    367.78
  • Formula:
    C20H14ClNO4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    5578-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1.
    Vogt et al.
    J.Biol.Chem., 2005;280:19078
  2. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.
    Aburai et al.
    Biosci.Biotechnol.Biochem., 2010;74:548
  3. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
    Adhami et al.
    Mol.Cell Ther., 2004;3:934
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
    Authors: Kenny Et al.
    PLoS One 2015;6:6220
  2. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.
    Authors: Candas Et al.
    Cancer Res 2014;74:7498
  3. The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
    Authors: Bavaria Et al.
    Apoptosis 2014;19:467

Have you used Sanguinarine chloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information