Sanguinarine chloride

Catalog # Availability Size / Price Qty
Sanguinarine chloride | CAS No. 5578-73-4 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Inhibitor of protein phosphatase 2C (PP2C)

Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

Purity: ≥97%

Product Details
Citations (4)

Biological Activity

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data

Soluble to 10 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1.
    Vogt et al.
    J.Biol.Chem., 2005;280:19078
  2. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.
    Aburai et al.
    Biosci.Biotechnol.Biochem., 2010;74:548
  3. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
    Adhami et al.
    Mol.Cell Ther., 2004;3:934

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Citations for Sanguinarine chloride

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4 Citations: Showing 1 - 4


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