Sanguinarine chloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2302
Chemical Name:13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Product Details
Citations (3)
Reviews
Biological Activity
Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.
Technical Data
  • M.Wt:
    367.78
  • Formula:
    C20H14ClNO4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at +4°C
  • CAS No:
    5578-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

3 Citations: Showing 1 - 3
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  1. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
    Authors: Kenny Et al.
    PLoS One  2015;6:6220
  2. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.
    Authors: Candas Et al.
    Cancer Res  2014;74:7498
  3. The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
    Authors: Bavaria Et al.
    Apoptosis  2014;19:467

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