Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Biological ActivitySanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.
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The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1.
Vogt et al.
Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.
Aburai et al.
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
Adhami et al.
Mol.Cell Ther., 2004;3:934
Citations for Sanguinarine chloride
The citations listed below are publications that use Tocris products. Selected citations for Sanguinarine chloride include:
4 Citations: Showing 1 - 4
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.
Authors: Pereira Et al.
Cell Rep 2018;23:1124
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Authors: Kenny Et al.
PLoS One 2015;6:6220
Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.
Authors: Candas Et al.
Cancer Res 2014;74:7498
The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
Authors: Bavaria Et al.
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