Sazetidine A dihydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2736
Chemical Name:6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). May act as a silent desensitizer or as an agonist, depending on subunit stoichiometry (EC50 = 1.1 nM for nAChR-stimulated dopamine release). Exhibits analgesic activity in vivo and significantly reduces nicotine self-administration in an experimental rat model.
Technical Data
  • M.Wt:
    333.25
  • Formula:
    C15H20N2O2.2HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1197329-42-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sazetidine A dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
    Authors: Kiguchi
    J Neuroinflammation  2018;15(1):96
  2. Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
    Authors: Brown and Wonnacott
    PLoS One  2015;40:2047
  3. Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs.
    Authors: Kuryatov Et al.
    Nat Commun  2013;8:e62246

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