SB 216641 hydrochloride

Tocris Bioscience | Catalog # 1242

Selective h5-HT1B antagonist
Tocris Bioscience

Key Product Details

Description

Selective h5-HT1B antagonist
View all 5-HT1B Receptor Antagonists »

Product Description

SB 216641 hydrochloride is a selective h5-HT1B antagonist with approximately 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for SB 216641 hydrochloride

Molecular Weight

523.03

Formula

C28H30N4O4.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride

CAS Number

193611-67-5

PubChem ID

10392025

InChI Key

JPBMDMNORXKGHZ-UHFFFAOYSA-N

SMILES

Cl.COC1=C(OCCN(C)C)C=C(NC(=O)C2=CC=C(C=C2)C2=CC=C(C=C2C)C2=NOC(C)=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.15 50

Preparing Stock Solutions for SB 216641 hydrochloride

The following data is based on the product molecular weight 523.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.82 mL 19.12 mL 38.24 mL
2.5 mM 0.76 mL 3.82 mL 7.65 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for SB 216641 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 216641 hydrochloride

For research use only

Citations for SB 216641 hydrochloride

Customer Reviews for SB 216641 hydrochloride (1)

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  • Excellent product
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: CHO
    Verified Customer | Posted 06/03/2020
    After reaching 80% confluence, cells were treated with the selective 5-HT2CR antagonist SB242084 (300nM) or the 5-HT1BR antagonist SB216641 (1µM), applied 10 minutes prior to agonist application.
    1µM
    SB 216641 hydrochloride 1242

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