Catalog Number: 1242
Chemical Name: N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
Biological Activity
A selective h5-HT1B antagonist with approximately 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.
    Price et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:312
  2. Effects of selective h5-HT1B (SB-216641) and 5-HT1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors.
    Schlicker et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:321
  3. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.
    Hagan et al.
    Eur.J.Pharmacol., 1997;331:169

The citations listed below are publications that use Tocris products. Selected citations for SB 216641 hydrochloride include:

Showing Results 1 - 3 of 3

  1. Expression of serotonin receptors in human hepatocellular cancer.
    Authors: Soll Et al.
    Clin Cancer Res
  2. Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.
    Authors: Dunbar Et al.
    J Physiol
  3. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    J Biol Chem
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