Potent and selective non-peptide NK3
receptor antagonist (Ki
values are 4.4, > 100,000 and 250 nM for human NK3
receptors respectively). Antihypertensive in vivo
. Brain penetrant.
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In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Medhurst et al.
Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats.
De Brito Gariepy and Couture
Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
Sarau et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 222200 include:
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