Catalog Number: 1393
Chemical Name: 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
Biological Activity
Potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant.
Technical Data
  • M.Wt:
    380.48
  • Formula:
    C26H24N2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    174635-69-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
    Medhurst et al.
    Br.J.Pharmacol., 1997;122:469
  2. Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats.
    De Brito Gariepy and Couture
    Br.J.Pharmacol., 2010;161:1868
  3. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
    Sarau et al.
    J.Pharmacol.Exp.Ther., 2000;295:373
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 222200 include:

2 Citations: Showing 1 - 2
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  1. Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis.
    Authors: Stein Et al.
    J Innate Immun 2009;1:618
  2. Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
    Authors: Gallopin Et al.
    Mol Cancer 2006;16:1440
Average Rating: 4 (Based on 1 review)

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