SB 265610

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2724/10
2724/50
2724/1
SB 265610 | CAS No. 211096-49-0 | Chemokine Receptor Antagonists
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Description: Potent CXCR2 antagonist

Chemical Name: N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products
Reviews

Biological Activity

Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

Technical Data

M.Wt:
357.16
Formula:
C14H9BrN6O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
211096-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats.
    Auten et al.
    J.Pharmacol.Exp.Ther., 2001;299:90
  2. Impaired healing of nitrogen mustard wounds in CXCR2 null mice.
    Milatovic et al.
    Wound Repair Regen., 2003;11:213

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Citations for SB 265610

The citations listed below are publications that use Tocris products. Selected citations for SB 265610 include:

8 Citations: Showing 1 - 8

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