Chemical Name: N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Biological ActivitySB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats.
Auten et al.
Impaired healing of nitrogen mustard wounds in CXCR2 null mice.
Milatovic et al.
Wound Repair Regen., 2003;11:213
Citations for SB 265610
The citations listed below are publications that use Tocris products. Selected citations for SB 265610 include:
8 Citations: Showing 1 - 8
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
Authors: He Et al.
CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.
Authors: Jung Et al.
Stem Cells Dev 2016;25:1006
Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair.
Authors: Bieren Et al.
PLoS Pathog 2015;11:e1004778
A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling.
Authors: Ha Et al.
Br J Pharmacol 2014;171:1551
Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
Authors: Toh Et al.
PLoS Biol 2011;9:e1001162
Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor.
Authors: Halpern Et al.
Cancer Lett 2011;308:91
Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
Authors: Burton Et al.
IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo.
Authors: Lavoie-Lamoureux Et al.
Am J Physiol Lung Cell Mol Physiol 2010;299:L472
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