Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA2
= 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB1
receptors, voltage-gated Ca2+
channels and the hyperpolarization-activated current (Ih
). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.
Fowler et al.
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.
Gavva et al.
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.
Gunthorpe et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 366791 include:
Showing Results 1 - 9 of 9