SB 366791

Catalog # Availability Size / Price Qty
1615/10
1615/50
SB 366791 | CAS No. 472981-92-3 | TRPV Antagonists
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Description: Potent and selective TRPV1 competitive antagonist

Chemical Name: 4'-Chloro-3-methoxycinnamanilide

Purity: ≥99%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

SB 366791 is a potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB1 and CB2 receptors, voltage-gated Ca2+ channels and the hyperpolarization-activated current (Ih).

Technical Data

M.Wt:
287.75
Formula:
C16H14ClNO2
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
472981-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Product Datasheets

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Citations for SB 366791

The citations listed below are publications that use Tocris products. Selected citations for SB 366791 include:

14 Citations: Showing 1 - 10

  1. The Cancer Chemotherapeutic PacT. Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.
    Authors: Li Et al.
    J Neurosci  2015;35:13487
  2. Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
    Authors: Nguyen Et al.
    Neuropsychopharmacology  2014;39:2414
  3. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
    Authors: Wang Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;307:G719
  4. Pharmacodynamics of TRPV1 agonists in a bioassay using human PC-3 cells.
    Authors: Alvarez-Berdugo Et al.
    ScientificWorldJournal  2014;2014:184526
  5. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Mol Pain  2013;305:F396
  6. Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide.
    Authors: Ambrosino Et al.
    Br J Pharmacol  2013;168:1430
  7. Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1.
    Authors: Graham Et al.
    J Cell Sci  2013;126:4602
  8. Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
    Authors: Casarotto Et al.
    Am J Physiol Renal Physiol  2012;37:478
  9. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust.
    Authors: Hazari Et al.
    Environ Health Perspect  2011;119:951
  10. Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.
    Authors: Westlund Et al.
    J Biol Chem  2010;6:46

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