SB 366791

Key Product Details

Product Description

SB 366791 is a potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA₂ = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB₁ and CB₂ receptors, voltage-gated Ca²⁺ channels and the hyperpolarization-activated current (I_h).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 366791

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 366791

The following data is based on the product molecular weight 287.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.38 mL	34.75 mL
5 mM	0.70 mL	3.48 mL	6.95 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 92 publications citing the usage of this product.

• Gavva Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 2005 PMID: 16135784
• Gunthorpe Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 2004 PMID: 14654105
• Fowler Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 2003 PMID: 12948856

Product Documents for SB 366791