SB 706504

Catalog # Availability Size / Price Qty
5040/10
5040/50
SB 706504 | CAS No. 911110-38-8 | p38 Inhibitors
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Description: p38 MAPK inhibitor

Chemical Name: N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine

Purity: ≥98%

Product Details
Reviews

Biological Activity

p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Effects on suppression of LPS-induced gene and protein expression are enhanced in combination with dexamethasone (Cat. No. 1126).

Technical Data

M.Wt:
492.46
Formula:
C24H19F3N8O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
911110-38-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Product Datasheets

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