SB 772077B dihydrochloride

Key Product Details

Product Description

SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC₅₀ value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat. No 1254) or Fasudil (Cat. No. 0541).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 772077B dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 772077B dihydrochloride

The following data is based on the product molecular weight 415.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.04 mL	24.08 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dhaliwal Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J.Pharm.Exp.Ther.
• Doe Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J.Pharmacol.Exp.Ther. 2007 PMID: 17018693

Product Documents for SB 772077B dihydrochloride