Fasudil hydrochloride

Catalog # Availability Size / Price Qty
Fasudil hydrochloride | CAS No. 105628-07-7 | Rho-kinase Inhibitors
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Description: Inhibitor of cyclic nucleotide dependent- and Rho-kinases
Alternative Names: HA 1077

Purity: ≥98%

Product Details
Citations (16)

Biological Activity

Fasudil hydrochloride is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Fasudil suppresses MMP-2 expression and induces apoptosis in glioblastoma cells in vivo. Fasudil is a Ca2+ antagonist, vasodilator and inhibits proliferation of vascular smooth muscle cells. Fasudil binds to α-synuclein to reduce aggregate formation in cellular models of Parkinson's disease, also displays neuroprotective properties and increases survival of dopaminergic neurons in vivo.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Fasudil hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Fasudil hydrochloride include:

16 Citations: Showing 1 - 10

  1. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogenemediated changes of cell mechanical properties.
    Authors: Panciera Et al.
    Nat Mater  2020;19:797
  2. Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension.
    Authors: Fazakas Et al.
    Front Physiol  2018;9:537
  3. Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma.
    Authors: Pitha Et al.
    Transl Vis Sci Technol  2018;7:6
  4. The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling.
    Authors: Flavahan and Flavahan
    Am J Physiol Heart Circ Physiol  2014;307:H628
  5. A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
    Authors: Bailey Et al.
    J Biol Chem  2014;289:30443
  6. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
    Authors: Akhtar Et al.
    PLoS One  2013;8:e67813
  7. The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.
    Authors: Lim Et al.
    PLoS One  2012;7:e35177
  8. Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
    Authors: Wang Et al.
    BMC Ear Nose Throat Disord  2012;61:2134
  9. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Authors: Jeyaraj Et al.
    Br J Pharmacol  2012;303:C499
  10. STAT inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    Authors: Díez Et al.
    PLoS One  2010;5:e14145


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