Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50
= 10.7 μ
M). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo
antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.
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All Tocris products are intended for laboratory research use only.
A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.
Shirotani et al.
Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils.
Satoh et al.
Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.
Sward et al.
Inhibition by the protein kinase inhibitor HA-1077 of the activation of NADPH oxidase in human neutrophils.
Arai et al.
Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.
Deng et al.
Cancer Biol Ther., 2010;875:875
The citations listed below are publications that use Tocris products. Selected citations for Fasudil hydrochloride include:
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