Fasudil hydrochloride

  ( 12 citations )    
Product Datasheet
Catalog Number:0541
Alternate Names:HA 1077
Chemical Name:
Product Details
Citations (12)
Reviews
Biological Activity
Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo. Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.
Technical Data
  • M.Wt:
    327.83
  • Formula:
    C14H17N3O2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    105628-07-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fasudil hydrochloride include:

12 Citations: Showing 1 - 10
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  1. The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling.
    Authors: Flavahan and Flavahan
    Am J Physiol Heart Circ Physiol  2014;307:H628
  2. A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
    Authors: Bailey Et al.
    J Biol Chem  2014;289:30443
  3. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
    Authors: Akhtar Et al.
    PLoS One  2013;8:e67813
  4. Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
    Authors: Wang Et al.
    BMC Ear Nose Throat Disord  2012;61:2134
  5. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Authors: Jeyaraj Et al.
    Br J Pharmacol  2012;303:C499
  6. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    Authors: Díez Et al.
    PLoS One  2010;5:e14145
  7. Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
    Authors: Choi Et al.
    Diabetes  2009;82:324
  8. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
    Authors: Inan and Büyükafşar
    J Neurosci  2008;155:44
  9. Rho-associated kinase inhibitor Y-27632 promotes survival of cynomolgus monkey embryonic stem cells.
    Authors: Takehara Et al.
    Mol Hum Reprod  2008;14:627
  10. Endothelin-1, via ETA receptor and independently of transforming growth factor-β, increases the connective tissue growth factor in vascular smooth muscle cells.
    Authors: Rodríguez-Vita Et al.
    Cardiovasc Res  2005;97:125
  11. Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss.
    Authors: Scherer Et al.
    Am J Physiol Cell Physiol  2005;5:10
  12. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.
    Authors: Wibberley Et al.
    Br J Pharmacol  2003;138:757
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