SC 26196

Catalog # Availability Size / Price Qty
SC 26196 | CAS No. 218136-59-5 | Lipid Metabolism Inhibitors
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Description: Selective fatty acid desaturase 2 inhibitor

Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

SC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Technical Data

Soluble to 25 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells.
    Li et al.
    Cell Stem Cell, 2017;20:1
  2. Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
    Obukowicz et al.
    J.Pharmacol.Exp.Ther., 1998;287:157
  3. Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis.
    Hansen-Petrik et al.
    Cancer Lett., 2002;175:157
  4. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.
    Zhang et al.
    J.Biomol.Screen., 2010;15:169

Product Datasheets

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Citation for SC 26196

The citations listed below are publications that use Tocris products. Selected citations for SC 26196 include:

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