Catalog Number: 4189
Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Biological Activity
Selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
Technical Data
  • M.Wt:
    423.55
  • Formula:
    C27H29N5
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    218136-59-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
    Obukowicz et al.
    J.Pharmacol.Exp.Ther., 1998;287:157
  2. Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis.
    Hansen-Petrik et al.
    Cancer Lett., 2002;175:157
  3. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.
    Zhang et al.
    J.Biomol.Screen., 2010;15:169
  4. Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells.
    Li et al.
    Cell Stem Cell, 2017;20:1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SC 26196 include:

1 Citations: Showing 1 - 1

  1. Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
    Authors: Rees Et al.
    PLoS One 2016;12:109

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