Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Biological ActivitySelective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells.
Li et al.
Cell Stem Cell, 2017;20:1
Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
Obukowicz et al.
Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis.
Hansen-Petrik et al.
Cancer Lett., 2002;175:157
A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.
Zhang et al.
Citation for SC 26196
The citations listed below are publications that use Tocris products. Selected citations for SC 26196 include:
1 Citation: Showing 1 - 1
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Authors: Rees Et al.
PLoS One 2016;12:109
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