Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Biological ActivitySC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells.
Li et al.
Cell Stem Cell, 2017;20:1
Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
Obukowicz et al.
Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis.
Hansen-Petrik et al.
Cancer Lett., 2002;175:157
A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.
Zhang et al.
Citation for SC 26196
The citations listed below are publications that use Tocris products. Selected citations for SC 26196 include:
1 Citation: Showing 1 - 1
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Authors: Rees Et al.
PLoS One 2016;12:109
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for SC 26196
There are currently no reviews for this product. Be the first to review SC 26196 and earn rewards!
Have you used SC 26196?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image