SC 26196

Key Product Details

Product Description

SC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ⁶ desaturase) inhibitor (IC₅₀ = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ⁵ desaturase and SCD-1/Δ⁹ desaturase, respectively) (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for SC 26196

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SC 26196

The following data is based on the product molecular weight 423.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.44 mL	47.22 mL	94.44 mL
1.25 mM	1.89 mL	9.44 mL	18.89 mL
2.5 mM	0.94 mL	4.72 mL	9.44 mL
12.5 mM	0.19 mL	0.94 mL	1.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Li Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 2017 PMID: 28041894
• Hansen-Petrik Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 2002 PMID: 11741743
• Zhang A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 2010 PMID: 20086206
• Obukowicz Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 1998 PMID: 9765335

Product Documents for SC 26196