SCH 202676 hydrobromide

Tocris Bioscience | Catalog # 1400

Inhibitor of ligand binding to G-protein-coupled receptors
Tocris Bioscience

Key Product Details

Description

Inhibitor of ligand binding to G-protein-coupled receptors
View all G Protein (Heterotrimeric) Inhibitors »

Product Description

SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).

Product Specifications for SCH 202676 hydrobromide

Molecular Weight

348.26

Formula

C15H13N3S.HBr

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide

CAS Number

265980-25-4

PubChem ID

9884675

InChI Key

YJYGOWVFDGULLL-UHFFFAOYSA-N

SMILES

C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.71 25 with gentle warming

Preparing Stock Solutions for SCH 202676 hydrobromide

The following data is based on the product molecular weight 348.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.49 mL 57.43 mL 114.86 mL
1.25 mM 2.30 mL 11.49 mL 22.97 mL
2.5 mM 1.15 mL 5.74 mL 11.49 mL
12.5 mM 0.23 mL 1.15 mL 2.30 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

Product Documents for SCH 202676 hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SCH 202676 hydrobromide

For research use only

Citations for SCH 202676 hydrobromide

Customer Reviews for SCH 202676 hydrobromide (1)

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  • Effective but not very stable
    Name: Sijia He
    Assay Type: In Vitro
    Cell Line/Tissue: Hepatocyte
    Verified Customer | Posted 10/25/2018
    Used as GPCR inhibitor for Glucagon treatment in mouse primary hepatocytes. As shown in the picture, from left to right, 1st sample is untreated, 2nd sample was treated with Glucagon, 3rd sample was pre-treated with this chemical plus glucagon, seems pretty effective for inhibiting glucagon stimulated p-CREB activation. however this chemical is not very stable, seems to loose effectiveness after short storage. Overall is happy with this product.
    SCH 202676 hydrobromide 1400

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