Catalog Number: 1400
Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Biological Activity
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
    Fawzi et al.
    Mol.Pharmacol., 2001;59:30
  2. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
    Gao et al.
    Life Sci., 2004;74:3173
  3. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.
    Lewandowicz et al.
    Br.J.Pharmacol., 2006;147:422
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