Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50
values are 0.1-1.8 μ
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All Tocris products are intended for laboratory research use only.
SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
Fawzi et al.
Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
Gao et al.
Life Sci., 2004;74:3173
The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.
Lewandowicz et al.