Selective adenosine A2A
receptor antagonist; binds to human and rat A2A
receptors with high affinity (Ki
values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A
over hA1 in vitro
with minimal affinity for hA2B
> 10 μ
M). Blocks the cytoprotective effect of A2A
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Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography.
Todde et al.
Protective roles of adenosine A1, A2, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Zheng et al.
Am.J.Physiol.Heart Circ.Physiol., 2007;293:3685
The citations listed below are publications that use Tocris products. Selected citations for SCH 442416 include:
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