CGS 21680 hydrochloride

  ( 64 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1063
Chemical Name:4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride
Product Details
Citations (64)
Supplemental Products
Reviews
Biological Activity
A2A adenosine receptor agonist (Ki = 27 nM). Has affinity for A1 and A3 adenosine receptors but can be used to distinguish A2A- and A2B-mediated effects.
Technical Data
  • M.Wt:
    535.99
  • Formula:
    C23H29N7O6.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    124431-80-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGS 21680 hydrochloride include:

64 Citations: Showing 1 - 10
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  1. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
    Authors: Liu Et al.
    Scientific Reports  2016;6:33614
  2. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
    Authors: Caiazzo Et al.
    Biochem.Pharmacol.  2016;112:72
  3. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling  2016;
  4. Role of adenosine receptor subtypes in methamphetamine reward and reinforcement.
    Authors: Kavanagh Et al.
    J Neurogenet  2015;89:265
  5. Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death.
    Authors: Tosolini Et al.
    Psychopharmacology (Berl)  2015;35:479
  6. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
    Authors: Kermanian Et al.
    Eneuro  2015;28:120
  7. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
    Authors: Wydra Et al.
    Am J Respir Cell Mol Biol  2015;232:1767
  8. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Mol Cell Biol  2015;2
  9. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
    Authors: Perez-Aso Et al.
    Arthritis Res Ther  2015;17:249
  10. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
    Authors: Eusemann Et al.
    PLoS One  2015;10:e0134934
  11. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Authors: Ziemlinska Et al.
    PLoS One  2014;9:e88833
  12. Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.
    Authors: Ahsan and Mehal
    Front Pharmacol  2014;5:69
  13. IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
    Authors: Perígolo-Vicente Et al.
    Biochem Biophys Res Commun  2014;449:477
  14. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
    Authors: Ruby Et al.
    Kidney Int  2014;39:2432
  15. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci  2014;31:237
  16. Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats.
    Authors: O'Neill Et al.
    Psychopharmacology (Berl)  2014;231:3179
  17. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
    Authors: Welihinda and Amento
    J Inflamm (Lond)  2014;11:37
  18. Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
    Authors: Xiao Et al.
    PLoS One  2013;8:e60173
  19. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol  2013;85:1171
  20. Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
    Authors: Fernández-Dueñas Et al.
    FASEB J  2013;63:42
  21. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
    Authors: Aggarwal Et al.
    Neuropsychopharmacology  2013;48:635
  22. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
    Authors: Matos Et al.
    J Neurosci  2013;33:18492
  23. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
    Authors: Yang Et al.
    J Cereb Blood Flow Metab  2013;33:1612
  24. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
    Authors: Loram Et al.
    Brain Behav Immun  2013;33:112
  25. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.
    Authors: Bao Et al.
    J Biol Chem  2013;288:22650
  26. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
    Authors: Wiseman Et al.
    J Biol Chem  2013;288:17803
  27. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He Et al.
    FASEB J  2013;27:3446
  28. Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
    Authors: Thomas Et al.
    Bioorg Med Chem  2013;21:7453
  29. Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.
    Authors: Garção Et al.
    Br J Pharmacol  2013;169:1600
  30. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
    Authors: Mills Et al.
    J Neurochem  2012;9:193
  31. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol  2012;86:10338
  32. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
    Authors: Park Et al.
    Kidney Int  2012;82:878
  33. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
    Authors: Lee Et al.
    PLoS One  2012;7:e38865
  34. Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats.
    Authors: Hobson Et al.
    Neuropharmacology  2012;63:1172
  35. Adenosine A2A receptor activation prevents wear particle-induced osteolysis.
    Authors: Mediero Et al.
    Sci Transl Med  2012;4:135ra65
  36. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.
    Authors: O'Neill Et al.
    Neuropsychopharmacology  2012;37:1245
  37. Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection.
    Authors: Jeon Et al.
    Neurochem Int  2012;20:27
  38. Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.
    Authors: Fernández-Dueñas Et al.
    J Immunol  2012;123:373
  39. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
    Authors: Garcia Et al.
    PLoS One  2011;80:378
  40. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.
    Authors: Kiebala and Maggirwar
    PLoS One  2011;6:e18633
  41. Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.
    Authors: Su Et al.
    Cancer Immunol Immunother  2011;60:111
  42. Adenosine-induced activation of esophageal nociceptors.
    Authors: Ru Et al.
    Am J Physiol Gastrointest Liver Physiol  2011;300:G485
  43. Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase.
    Authors: Carlström Et al.
    Am J Physiol Renal Physiol  2011;300:F457
  44. Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists.
    Authors: Das Et al.
    J Nanobiotechnology  2010;8:11
  45. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
    Authors: Keene Et al.
    Biochem Pharmacol  2010;80:188
  46. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
    Authors: Wang Et al.
    Biomol Ther (Seoul)  2010;5:e13883
  47. The A2aR adenosine receptor controls cytokine production in iNKT cells.
    Authors: Nowak Et al.
    Neuropharmacology  2010;40:682
  48. Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
    Authors: Hiranita Et al.
    J Pharmacol Exp Ther  2010;332:515
  49. Adenosine can mediate its actions through generation of reactive oxygen species.
    Authors: Gebremedhin Et al.
    J Cereb Blood Flow Metab  2010;30:1777
  50. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  51. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
    Authors: Zhou Et al.
    J Clin Invest  2010;120:2280
  52. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci  2010;11:7
  53. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol  2009;47:684
  54. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
    Authors: Epperson Et al.
    Am J Physiol Cell Physiol  2009;296:C1171
  55. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments.
    Authors: Ohta Et al.
    Eur J Immunol  2009;183:5487
  56. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
    Authors: Pugliese Et al.
    Br J Pharmacol  2009;157:818
  57. Dichotomous dopaminergic control of striatal synaptic plasticity.
    Authors: Shen Et al.
    Science  2008;321:848
  58. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.
    Authors: Garcia Et al.
    J Neuroinflammation  2008;22:445
  59. Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.
    Authors: Keir Et al.
    Br J Pharmacol  2006;147:720
  60. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
    Authors: Yang Et al.
    J Clin Invest  2006;116:1913
  61. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
    Authors: Kornerup Et al.
    Br J Pharmacol  2005;144:1011
  62. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
    Authors: Germack and Dickenson
    Br J Pharmacol  2004;141:329
  63. Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
    Authors: Nieri Et al.
    Br J Pharmacol  2001;134:745
  64. Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release.
    Authors: Ezeamuzie and Philips
    Br J Pharmacol  1999;127:188
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Species Human

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