CGS 21680 hydrochloride

Tocris Bioscience | Catalog # 1063

A2A agonist
Tocris Bioscience

Key Product Details

Description

A2A agonist
View all Adenosine A2a Receptor Agonists »

Product Description

CGS 21680 hydrochloride is a potent A2A adenosine receptor agonist (Ki = 27 nM, EC50 = 1.48-180 nM). CGS 21680 reduces venous resistance, increases heart rate and cardiac output in vivo. In an animal model of Huntington's disease, CGS21680 slows motor deterioration, prevents reduction in brain weight and reduces the size of mutant huntingtin aggregates and intranuclear inclusions. CGS21680 increases proliferation of neural progenitor cells, promotes survival of motoneurons and activates TrkB receptors. Also has anti-inflammatory effects in animal models of lung injury and reduces neurotoxicity induced by Kainate (Cat. No. 7065).

Product Specifications for CGS 21680 hydrochloride

Molecular Weight

535.99

Formula

C23H29N7O6.HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride

CAS Number

124431-80-7

PubChem ID

10256643

InChI Key

QPHVMNOEKKJYJO-MJWSIIAUSA-N

SMILES

NC1=NC(NCCC4=CC=C(CCC(O)=O)C=C4)=NC2=C1N=CN2[C@@H]3O[C@H]([C@](NCC)=O)[C@@H](O)[C@H]3O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.6 100

Preparing Stock Solutions for CGS 21680 hydrochloride

The following data is based on the product molecular weight 535.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.66 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 93 publications citing the usage of this product.

Product Documents for CGS 21680 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGS 21680 hydrochloride

For research use only

Citations for CGS 21680 hydrochloride

Customer Reviews for CGS 21680 hydrochloride (3)

4.7 out of 5
3 Customer Ratings
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  • HEK cell line expressing A2A Receptor
    Name: Tahmineh Safaie
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/22/2021
    HEK cell line expressing A2A Receptor were treated with CGS in presence or absence of ZM241385 for 30 minutes and level of cAMP was measured.
    CGS 21680 hydrochloride 1063
  • works on inhibited CD4 cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 06/05/2018
    Works perfectly on my CD4 T cells proliferation assay, when detected by CFSE. It inhibited the proliferation of activated CD4 cells in dose-dependent manner.
    CGS 21680 hydrochloride 1063
  • Cell based assays
    Name: Anonymous
    Verified Customer | Posted 12/01/2017
    HGF protein
    receptors, antibody or ILISA Kits

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