SCIO 469 hydrochloride

Catalog # Availability Size / Price Qty
3528/10
3528/50
SCIO 469 hydrochloride | p38 Inhibitors
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Description: Selective p38 MAPK inhibitor

Chemical Name: 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells.

Technical Data

M.Wt:
549.46
Formula:
C27H30ClFN4O3.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SCIO 469 hydrochloride

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2 Citations: Showing 1 - 2

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