SGC-CBP30

Catalog # Availability Size / Price Qty
4889/10
4889/50
Cat.No. 4889 - SGC-CBP30 | C28H33ClN4O3
1 Image
Description: Potent CBP/p300 BRD inhibitor

Chemical Name: 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent CBP/p300 bromodomain (BRD) inhibitor (Kd values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC-CBP30 is reviewed on the chemical probes website.

Technical Data

M.Wt:
509.04
Formula:
C28H33ClN4O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-CBP30 probe summary on the SGC website.

Background References

  1. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.
    Hay et al.
    J.Am.Chem.Soc., 2014;136:9308
  2. Bromodomains and their pharmacological inhibitors.
    Gallenkamp et al.
    ChemMedChem, 2014;9:438
  3. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
    Hammitzsch et al.
    Proc.Natl.Acad.Sci.U.S.A., 2015;112:10768

Product Datasheets

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