Chemical Name: 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole
Biological ActivitySGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor (Kd values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC-CBP30 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.
Hay et al.
Bromodomains and their pharmacological inhibitors.
Gallenkamp et al.
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
Hammitzsch et al.
Citation for SGC-CBP30
The citations listed below are publications that use Tocris products. Selected citations for SGC-CBP30 include:
1 Citation: Showing 1 - 1
A conserved enhancer regulates Il9 expression in multiple lineages.
Authors: Koh Et al.
Nat Commun 2018;9:4803
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for SGC-CBP30
There are currently no reviews for this product. Be the first to review SGC-CBP30 and earn rewards!
Have you used SGC-CBP30?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image