SGC-CBP30

Tocris Bioscience | Catalog # 4889

Potent CBP/p300 BRD inhibitor
Tocris Bioscience

Key Product Details

Description

Potent CBP/p300 BRD inhibitor
View all Bromodomain Inhibitors »

Product Description

SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor (Kd values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM. SGC-CBP30 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-CBP30 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC-CBP30 is reviewed on the chemical probes website.

Product Specifications for SGC-CBP30

Molecular Weight

509.04

Formula

C28H33ClN4O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole

CAS Number

1613695-14-9

PubChem ID

72201027

InChI Key

GEPYBHCJBORHCE-SFHVURJKSA-N

SMILES

CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC(Cl)=C(OC)C=C4)N3C[C@@H](N5CCOCC5)C)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100
Ethanol 100

Preparing Stock Solutions for SGC-CBP30

The following data is based on the product molecular weight 509.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.82 mL 19.64 mL
5 mM 0.39 mL 1.96 mL 3.93 mL
10 mM 0.20 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for SGC-CBP30

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SGC-CBP30

For research use only

Customer Reviews for SGC-CBP30 (1)

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  • p300 inhibition
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: 293T
    Verified Customer | Posted 10/31/2022
    Used to inhibit p300 and downstream genes. We treated 293 cells with CBP30 and then detected p300 staining with IF. Figure: Green channel is p300 in nucleus
    SGC-CBP30 4889

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