HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo
following oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Statins and bone formation.
Garrett et al.
Potential anticancer effects of statins: fact or fiction?
Kaushal et al.
Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
Preclinical pharmacokinetics of statins.
Reinoso et al.
Methods Find.Exp.Clin.Pharmacol., 2002;24:593
The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:
Showing Results 1 - 3 of 3