Catalog Number: 1965
Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Biological Activity
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Deuterated analog also available.

Technical Data
  • M.Wt:
    418.57
  • Formula:
    C25H38O5
  • Solubility:
    Soluble to 50 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    79902-63-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Statins and bone formation.
    Garrett et al.
    Curr.Pharm.Des., 2001;7:715
  2. Potential anticancer effects of statins: fact or fiction?
    Kaushal et al.
    Endothelium, 2003;10:49
  3. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
    White
    J.Clin.Pharmacol., 1999;39:111
  4. Preclinical pharmacokinetics of statins.
    Reinoso et al.
    Methods Find.Exp.Clin.Pharmacol., 2002;24:593
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:

3 Citations: Showing 1 - 3
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  1. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Br J Pharmacol 2013;8:e66404
  2. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
    Authors: Vainio Et al.
    Pharmacol Res Perspect 2011;2:1176
  3. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
    Authors: Seto Et al.
    Oncotarget 2007;151:987
Tocris Small Molecules
Description Application Cat# Citations Images  

Simvastatin - d6

5536  
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