Simvastatin

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1965
Chemical Name:(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Product Details
Citations (3)
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Reviews
Biological Activity
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Deuterated analog also available.

Technical Data
  • M.Wt:
    418.57
  • Formula:
    C25H38O5
  • Solubility:
    Soluble to 50 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    79902-63-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:

3 Citations: Showing 1 - 3
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  1. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Br J Pharmacol  2013;8:e66404
  2. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
    Authors: Vainio Et al.
    Pharmacol Res Perspect  2011;2:1176
  3. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
    Authors: Seto Et al.
    Oncotarget  2007;151:987

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Average Rating: 5 (Based on 1 review)

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  Other Anonymous 03/22/2018
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Species Other

Other Experimental Details

Other Experimental Details It works well and the price is nice.

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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