Catalog # Availability Size / Price Qty
Simvastatin | CAS No. 79902-63-9 | HMG-CoA Reductase Inhibitors
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Description: HMG-CoA reductase inhibitor

Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

Purity: ≥98%

Product Details
Citations (4)

Biological Activity

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Technical Data

Soluble to 50 mM in DMSO and to 75 mM in ethanol
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Background References

  1. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels
    K Zhang, W Song, D Li, X Jin
    Exp Ther Med, 2017;13(5):1719-1724.
  2. STAT and bone formation.
    Garrett et al.
    Curr.Pharm.Des., 2001;7:715
  3. Potential anticancer effects of STAT: fact or fiction?
    Kaushal et al.
    Endothelium, 2003;10:49
  4. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
    J.Clin.Pharmacol., 1999;39:111
  5. Preclinical pharmacokinetics of STAT.
    Reinoso et al.
    Methods Find.Exp.Clin.Pharmacol., 2002;24:593

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Citations for Simvastatin

The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:

4 Citations: Showing 1 - 4


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