Simvastatin

Catalog # Availability Size / Price Qty
1965/50

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Simvastatin | CAS No. 79902-63-9 | HMG-CoA Reductase Inhibitors
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Description: HMG-CoA reductase inhibitor

Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Technical Data

M.Wt:
418.57
Formula:
C25H38O5
Solubility:
Soluble to 50 mM in DMSO and to 75 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
79902-63-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. STAT and bone formation.
    Garrett et al.
    Curr.Pharm.Des., 2001;7:715
  2. Potential anticancer effects of STAT: fact or fiction?
    Kaushal et al.
    Endothelium, 2003;10:49
  3. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
    White
    J.Clin.Pharmacol., 1999;39:111
  4. Preclinical pharmacokinetics of STAT.
    Reinoso et al.
    Methods Find.Exp.Clin.Pharmacol., 2002;24:593

Product Datasheets

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Citations for Simvastatin

The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:

4 Citations: Showing 1 - 4

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