Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Biological ActivityHMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
Deuterated analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
STAT and bone formation.
Garrett et al.
Potential anticancer effects of STAT: fact or fiction?
Kaushal et al.
Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
Preclinical pharmacokinetics of STAT.
Reinoso et al.
Methods Find.Exp.Clin.Pharmacol., 2002;24:593
Citations for Simvastatin
The citations listed below are publications that use Tocris products. Selected citations for Simvastatin include:
4 Citations: Showing 1 - 4
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
Br J Pharmacol 2013;8:e66404
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
Authors: Vainio Et al.
Pharmacol Res Perspect 2011;2:1176
Modulation by SimV. of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
Authors: Seto Et al.
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I used this drug to test the role of mevalonate pathway in joint integrity