SIRP alpha/CD172a Antibody (15-414) - BSA Free

Name: SIRP alpha/CD172a Antibody (15-414) - BSA Free
Brand: Novus Biologicals
SKU: NBP3-09153
Price: 339 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-09153

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2A Clone # 15-414

Format

BSA Free

View all SIRP alpha/CD172a Primary Antibodies »

Product Specifications

Immunogen

Kg-1a cell line

Specificity

The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Scientific Data Images for SIRP alpha/CD172a Antibody (15-414) - BSA Free

Flow Cytometry: SIRP alpha/CD172a Antibody (15-414) - BSA Free [NBP3-09153]

Flow Cytometry: SIRP alpha/CD172a Antibody (15-414) [NBP3-09153] - Analysis (surface staining) of human peripheral blood cells using anti-CD172a (15-414) purified, GAM-APC.

Applications for SIRP alpha/CD172a Antibody (15-414) - BSA Free

Application

Recommended Usage

Flow Cytometry

1-4 ug/ml

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Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

Phosphate buffered saline (PBS), pH 7.4

Format

BSA Free

Preservative

15mM Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIRP alpha/CD172a

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Long Name

Signal-regulatory Protein alpha

Alternate Names

BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA

Gene Symbol

SIRPA

Additional SIRP alpha/CD172a Products

Product Documents for SIRP alpha/CD172a Antibody (15-414) - BSA Free

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Certificate of Analysis

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Product Specific Notices for SIRP alpha/CD172a Antibody (15-414) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.