SMARCC1 Antibody

Novus Biologicals | Catalog # NB100-55312

Novus Biologicals
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all SMARCC1 Primary Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 300 and 350 of human SMARCC1/BAF155 using the numbering given in entry NP_003065.2 (GeneID 6599).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SMARCC1 Antibody

Western Blot: SMARCC1 Antibody [NB100-55312]

Western Blot: SMARCC1 Antibody [NB100-55312]

Western Blot: SMARCC1 Antibody [NB100-55312] - Detection of Human SMARCC1/BAF155 on HeLa whole cell lysate using NB100-55312. SMARCC1/BAF155 was also IPed by rabbit anti-SMARCC1/BAF155 antibodies NB100-55313 and NB100-55314.

Applications for SMARCC1 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: SMARCC1

SMARCC1 is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). It may stimulate the ATPase activity of the catalytic subunit of the complex. It is a component of five multiprotein chromatin remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. It may also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1.

Alternate Names

BAF155SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily C member 1, BRG1-associated factor 155, chromatin remodeling complex BAF155 subunit, CRACC1, mammalian chromatin remodeling complex BRG1-associated factor 155, Rsc8, SRG3, subfamily c, member 1, SWI/SNF complex 155 kDa subunit, SWI/SNF complex subunit SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, SWI3

Entrez Gene IDs

6599 (Human); 20588 (Mouse)

Gene Symbol

SMARCC1

UniProt

Q92922 (Human)

Additional SMARCC1 Products

Product Documents for SMARCC1 Antibody

Certificate of Analysis

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Product Specific Notices for SMARCC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for SMARCC1 Antibody

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