SMER 28

  ( 2 citations )    
Product Datasheet
Catalog Number:4297
Chemical Name:6-Bromo-N-2-propenyl-4-quinazolinamine
Product Details
Citations (2)
Reviews
Biological Activity
Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
Technical Data
  • M.Wt:
    264.12
  • Formula:
    C11H10BrN3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    307538-42-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SMER 28 include:

2 Citations: Showing 1 - 2
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  1. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.
    Authors: Cicero Et al.
    Sci Rep  2016;6:34798
  2. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell  2016;18:653

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