Catalog Number: 4297
Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine
Biological Activity
Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
Technical Data
  • M.Wt:
    264.12
  • Formula:
    C11H10BrN3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    307538-42-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.
    Renna et al.
    J.Biol.Chem., 2010;285:11061
  2. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
    Sarkar et al.
    Nat.Chem.Biol., 2010;3:331
  3. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Zhang et al.
    Cell Stem Cell, 2016;18:653
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SMER 28 include:

1 Citations: Showing 1 - 1

  1. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell 2016;18:653

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