Home / Autophagy-related Compounds / SMER 28

SMER 28

Catalog #: 4297
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4297/10
4297/50
SMER 28 | CAS No. 307538-42-7 | Autophagy-related Compounds
1 Image
Description: Positive regulator of autophagy

Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Technical Data

M.Wt:
264.12
Formula:
C11H10BrN3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
307538-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SMER 28

The citations listed below are publications that use Tocris products. Selected citations for SMER 28 include:

3 Citations: Showing 1 - 3

  1. The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A.
    Authors: Puri Et al.
    Dev Cell  2018;45:114
  2. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.
    Authors: Cicero Et al.
    Sci Rep  2016;6:34798
  3. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
    Authors: Zhang Et al.
    Cell Stem Cell  2016;18:653

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SMER 28

There are currently no reviews for this product. Be the first to review SMER 28 and earn rewards!

Have you used SMER 28?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.