Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α
-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
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Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.
Renna et al.
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar et al.
Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation.
Zhang et al.
Cell Stem Cell, 2016;18:653
The citations listed below are publications that use Tocris products. Selected citations for SMER 28 include:
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