SMER 3

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SMER 3 | CAS No. 67200-34-4 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective inhibitor of E3 ubiquitin ligase

Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Purity: ≥98%

Product Details
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Biological Activity

Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Technical Data

M.Wt:
224.18
Formula:
C11H4N4O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
67200-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor.
    Aghajanyy et al.
    Nat.Biotechnol., 2010;28:738

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