Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Biological ActivitySMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).
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Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor.
Aghajanyy et al.
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