SNIPER(ER)-87

Tocris Bioscience | Catalog # 7120

Potent and selective ERα Degrader (SNIPER)
Tocris Bioscience

Key Product Details

Description

Potent and selective ERα Degrader (SNIPER)
View all Active Degraders »

Product Description

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

Product Specifications for SNIPER(ER)-87

Molecular Weight

1044.32

Formula

C59H73N5O10S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide

CAS Number

2222354-91-6

PubChem ID

155563319

InChI Key

ILLYWIKUEZHTSD-RJFLEHBVSA-N

SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(COCCOCCOCCOC3=CC(C(C4=CSC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=N4)=O)=CC=C3)=O)C)\C7=CC=C(C=C7)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 104.43 100

Preparing Stock Solutions for SNIPER(ER)-87

The following data is based on the product molecular weight 1044.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.79 mL 9.58 mL
5 mM 0.19 mL 0.96 mL 1.92 mL
10 mM 0.10 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.10 mL 0.19 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for SNIPER(ER)-87

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SNIPER(ER)-87

For research use only

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