Chemical Name: (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
Biological ActivitySNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat.No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs).
Ohoka et al.
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