SNIPER(ER)-87

Catalog # Availability Size / Price Qty
7120/5
SNIPER(ER)-87 | CAS No. 2222354-91-6 | Active Degraders
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Description: Potent and selective ERα Degrader (SNIPER)

Chemical Name: (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide

Purity: ≥98%

Product Details
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Biological Activity

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

Technical Data

M.Wt:
1044.32
Formula:
C59H73N5O10S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2222354-91-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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