Catalog Number: 3412
Alternate Names: 4-OH-TAM
Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Biological Activity
Estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
    Yu and Forman
    J.Org.Chem., 2003;68:9489
  2. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.
    Jordan et al.
    J.Endocrinology, 1977;75:305
  3. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6.
    Desta et al.
    J.Pharm.Exp.Ther., 2004;310:1062
  4. Small molecule-triggered Cas9 protein with improved genome-editing specificity.
    Davis et al.
    Nat.Chem.Biol., 2015;11:316
Tocris Small Molecules
Description Application Cat# Citations Images  

Tamoxifen citrate

0999 7  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used (Z)-4-Hydroxytamoxifen?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 


Customer Information