Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Biological ActivityEstrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
Yu and Forman
Small molecule-triggered Cas9 protein with improved genome-editing specificity.
Davis et al.
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.
Jordan et al.
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6.
Desta et al.
Citation for (Z)-4-Hydroxytamoxifen
The citations listed below are publications that use Tocris products. Selected citations for (Z)-4-Hydroxytamoxifen include:
1 Citation: Showing 1 - 1
Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells.
Authors: Candelaria Et al.
PLoS One 2015;10:e0145061
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