(Z)-4-Hydroxytamoxifen

Tocris Bioscience | Catalog # 3412

Metabolite of tamoxifen (Cat. No. 0999)
Tocris Bioscience

Key Product Details

Description

Metabolite of tamoxifen (Cat. No. 0999)

Alternative Names

4-OH-TAM
View all Estrogen and Related Receptor Modulators »

Product Description

(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC50 = 27 μM). (Z)-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. (Z)-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9. (Z)-4-Hydroxytamoxifen binds to voltage-gated sodium channels, near the intracellular gate and inhibits the sodium current by delaying channel recovery from the inactivated state (IC50 values are 297 nM and 2.1 µM for NavM and human Nav, respectively in HEK cells); this inhibition is independent of estrogen receptor modulation. Chemotherapeutic agent.

Product Specifications for (Z)-4-Hydroxytamoxifen

Molecular Weight

387.51

Formula

C26H29NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

CAS Number

68047-06-3

PubChem ID

449459

InChI Key

TXUZVZSFRXZGTL-QPLCGJKRSA-N

SMILES

CC\C(C3=CC=CC=C3)=C(C2=CC=C(OCCN(C)C)C=C2)/C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.75 100
Ethanol 7.75 20

Preparing Stock Solutions for (Z)-4-Hydroxytamoxifen

The following data is based on the product molecular weight 387.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.90 mL 25.81 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

Product Documents for (Z)-4-Hydroxytamoxifen

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (Z)-4-Hydroxytamoxifen

For research use only

Citations for (Z)-4-Hydroxytamoxifen

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  • 4-hydroxytamoxifen for TRAPing cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/23/2019
    .5mg/ml dissolved in 1% tween 80 and 2.5% DMSO, injected 5mg/kg i.p.
    used for tamoxifen TRAPing using ERT-cre mice. given 3hrs post behavior. single dose was sufficient for recombination
    (Z)-4-Hydroxytamoxifen 3412

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