(Z)-4-Hydroxytamoxifen

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3412/10
3412/50
(Z)-4-Hydroxytamoxifen | CAS No. 68047-06-3 | Estrogen and Related Receptor Modulators
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Description: Metabolite of tamoxifen (Cat. No. 0999)
Alternative Names: 4-OH-TAM

Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
Reviews (1)

Biological Activity

Estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.

Technical Data

M.Wt:
387.51
Formula:
C26H29NO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
68047-06-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (Z)-4-Hydroxytamoxifen

The citations listed below are publications that use Tocris products. Selected citations for (Z)-4-Hydroxytamoxifen include:

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4-hydroxytamoxifen for TRAPing cells
By Anonymous on 05/23/2019
Species: Mouse

used for tamoxifen TRAPing using ERT-cre mice. given 3hrs post behavior. single dose was sufficient for recombination


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