Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Biological ActivityEstrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
Yu and Forman
Small molecule-triggered Cas9 protein with improved genome-editing specificity.
Davis et al.
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.
Jordan et al.
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6.
Desta et al.
Citation for (Z)-4-Hydroxytamoxifen
The citations listed below are publications that use Tocris products. Selected citations for (Z)-4-Hydroxytamoxifen include:
1 Citation: Showing 1 - 1
Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells.
Authors: Candelaria Et al.
PLoS One 2015;10:e0145061
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