Catalog Number: 3412
Alternate Names: 4-OH-TAM
Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Biological Activity
Estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
    Yu and Forman
    J.Org.Chem., 2003;68:9489
  2. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.
    Jordan et al.
    J.Endocrinology, 1977;75:305
  3. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6.
    Desta et al.
    J.Pharm.Exp.Ther., 2004;310:1062
  4. Small molecule-triggered Cas9 protein with improved genome-editing specificity.
    Davis et al.
    Nat.Chem.Biol., 2015;11:316
Tocris Small Molecules
Description Application Cat# Citations Images  

Tamoxifen citrate

0999 7  
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