Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Biological Activity(Z)-4-Hydroxytamoxifen is a estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.
Yu and Forman
Small molecule-triggered Cas9 protein with improved genome-editing specificity.
Davis et al.
A monohydroxylated metabolite of tamox. with potent antioestrogenic activity.
Jordan et al.
Comprehensive evaluation of tamox. sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6.
Desta et al.
Citations for (Z)-4-Hydroxytamoxifen
The citations listed below are publications that use Tocris products. Selected citations for (Z)-4-Hydroxytamoxifen include:
5 Citations: Showing 1 - 5
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation.
Authors: Zhang Et al.
Cell Stem Cell 2019;24:138
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.
Authors: Chatterjee Et al.
PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells.
Authors: Ito Et al.
NPJ Breast Cancer 2017;3:45
MTA1 is a novel regulator of autophagy that induces TAX resistance in breast cancer cells.
Authors: Lee Et al.
Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of tamox. in Breast Cancer Cells.
Authors: Candelaria Et al.
PLoS One 2015;10:e0145061
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for (Z)-4-Hydroxytamoxifen
Average Rating: 5 (Based on 1 Review)
Have you used (Z)-4-Hydroxytamoxifen?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
used for tamoxifen TRAPing using ERT-cre mice. given 3hrs post behavior. single dose was sufficient for recombination