SOCS-5 Antibody

Novus Biologicals | Catalog # NB100-56639

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all SOCS-5 Primary Antibodies »

Product Specifications

Immunogen

This polyclonal antibody was raised against a synthetic peptide containing amino acid residues of human SOCS5 protein. Human or mouse spleen lysate can be used as a positive control.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 19138703).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SOCS-5 Antibody

Western Blot: SOCS-5 Antibody [NB100-56639]

Western Blot: SOCS-5 Antibody [NB100-56639]

Western Blot: SOCS-5 Antibody [NB100-56639] - Analysis for SOCS5 using NB100-56639 at 1:500 dilution against 15 ug/lane of mouse spleen (lane A) and human spleen (lane B) lysates.

Applications for SOCS-5 Antibody

Application
Recommended Usage

Western Blot

1:500

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.1 mg/ml BSA.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-5

The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each member of the family has been determined by gene knockout experiments (1). SOCS5 protein is preferentially expressed in committed T-helper (Th1) cells. The action of SOCS5 is probably mediated by its interaction with the cytoplasmic domain of IL-4 receptor. During Th1 differentiation, there is a reduction in the association of Janus kinase 1 with the IL-4 receptor (IL-4R), which is correlated with the expression of SOCS5 pressor of cytokine signaling-5 (SOCS5). It has been also shown that in the overexpression of SOCS5 in transgenic mice leads to impaired Th2 development, suggesting that SOCS5 may plan an important role in the Th1 differentiation by regulating a balance between Th1 and Th2 (2).

Long Name

Suppressor Of Cytokine Signaling 5

Alternate Names

CIS6, CISH5, CISH6, SOCS5

Entrez Gene IDs

56468 (Mouse)

Gene Symbol

SOCS5

UniProt

O75159

Additional SOCS-5 Products

Product Documents for SOCS-5 Antibody

Certificate of Analysis

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Product Specific Notices for SOCS-5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for SOCS-5 Antibody

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