Sonic Hedgehog/Shh Antibody Blocking Peptide

Name: Sonic Hedgehog/Shh Antibody Blocking Peptide
Brand: Novus Biologicals
SKU: NBP2-22139PEP
Price: 139 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-22139PEP

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Applications

Antibody Competition

View all Sonic Hedgehog/Shh Proteins and Enzymes »

Product Specifications

Description

A Sonic Hedgehog/Shh antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for NBP2-22139. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation, and Storage

NBP2-22139PEP

Formulation	Peptide dissolved in dH2O. Contains no BSA.
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: Sonic Hedgehog/Shh

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal (1). Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene (2). Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo (3). A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma (4).

Alternate Names

HHG1, HLP3, HPE3, MCOPCB5, Shh, ShhNC, SMMCI, TPTPS

Gene Symbol

SHH

Additional Sonic Hedgehog/Shh Products

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Product Specific Notices for Sonic Hedgehog/Shh Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.