Sorbitol Dehydrogenase Antibody

Novus Biologicals | Catalog # NBP3-30587

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Sorbitol Dehydrogenase Primary Antibodies »

Product Specifications

Immunogen

between 307 and 357

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Sorbitol Dehydrogenase Antibody

Sorbitol Dehydrogenase Antibody

Western Blot:[NBP3-30587]-

Western Blot:[NBP3-30587]-Detection of human SORD by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa, HEK293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-SORD antibody used for WB at 0. 04 µg/ml and 0. 4 µg/ml and used for IP at 6 µg/mg lysate. SORD was also immunoprecipitated by rabbit anti-SORD antibody, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes and 10 seconds.

Applications for Sorbitol Dehydrogenase Antibody

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-buffered Saline 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Sorbitol Dehydrogenase

Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues. The enzyme has attracted considerable interest due to its implication in the development of diabetic complications as the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.

Alternate Names

EC 1.1.1, EC 1.1.1.14, L-iditol 2-dehydrogenase, sorbitol dehydrogenase, SORD1

Gene Symbol

SORD

Additional Sorbitol Dehydrogenase Products

Product Documents for Sorbitol Dehydrogenase Antibody

Certificate of Analysis

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Product Specific Notices for Sorbitol Dehydrogenase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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