SorLA Antibody (24GB13375)

Name: SorLA Antibody (24GB13375)
Brand: Novus Biologicals
SKU: NBP3-51914
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-51914

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2B Clone # 24GB13375

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Product Specifications

Immunogen

Recombinant protein of human SorLA (Uniprot: Q92673)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for SorLA Antibody (24GB13375)

Application

Recommended Usage

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SorLA

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Long Name

Sortilin-related Receptor Containing LDLR Class A Repeats

Alternate Names

gp250, LR11, LRP9, SORL1

Gene Symbol

SORL1

Additional SorLA Products

Product Documents for SorLA Antibody (24GB13375)

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Certificate of Analysis

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Product Specific Notices for SorLA Antibody (24GB13375)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Obesity

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