Catalog Number: 0952
Chemical Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
Biological Activity
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
    308.82
  • Formula:
    C12H20N2O3S.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    959-24-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'.
    Claudel and Touboul
    Pacing Clin.Electrophysiol., 1995;18:451
  2. Block of Iks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol.
    Fiset et al.
    J.Pharmacol.Exp.Ther., 1997;283:148
  3. Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines.
    Uloth et al.
    J.Med.Chem., 1966;9:88
  4. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
    Authors: Kaya Et al.
    J Neurosci 2009;329:350
  2. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron 2007;54:599

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