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SP 141

5332 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5332/10
5332/50
Ubiquitin Ligase (E3) Inhibitors Small Molecule
1 Image
Description: High affinity MDM2 inhibitor

Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

Purity: ≥98%

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Biological Activity

High affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.

Technical Data

M.Wt:
324.38
Formula:
C22H16N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1253491-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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