Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Biological ActivitySP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models.
Wang et al.
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