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SP 141

Catalog #: 5332 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5332/10
5332/50
SP 141 | CAS No. 1253491-42-7 | Ubiquitin Ligase (E3) Inhibitors
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Description: High affinity MDM2 inhibitor

Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

Purity: ≥98%

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Biological Activity

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Technical Data

M.Wt:
324.38
Formula:
C22H16N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1253491-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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